Triphenylphosphine → HCID 23592304, compound

Participants

Reaction Steps

To N-(2,5-dichlorophenyl)-4-chlorobenzenesulfonamide (5.0 g, 15 mmol), (S) -4-trityloxy-butan-2-ol (7.7 g, 22 mmol), and triphenylphosphine (5.8 g, 22 mmol) in THF (200 mL) at 0° C. was added diethyl azodicarboxylate (3.8 g, 22 mmol). The reaction was allowed to warm to ambient temperature with stirring 18 h The reaction was then diluted with EtOAc and washed with H2O, 1N HCl, and brine. The organic phase was dried over MgSO4, filtered, and concentrated in vacuo. Silica gel chromatography (15% EtOAc/hexanes) of the concentrate afforded the title compound as a white solid (5.25 g, 55% yield).

Provenance & Evidence