Ammonia → HCID 22254603, compound

HRID 1611691Notes

Reaction equation

HRID 1611691 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.[OH:12][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=1)[C:16](OC)=O.[NH3:23]>>[CH:1]1[C:10]2[C:5](=[C:6]([O:11][CH2:3][CH2:4][CH2:5][CH:6]([CH3:7])[O:12][C:13]3[CH:22]=[CH:21][CH:20]=[C:15]4[C:14]=3[N:23]=[C:1]([NH2:2])[CH:10]=[CH:16]4)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 30386Isoquinolin-5-olHCID 88068Methyl 3-Hydroxybenzoate

Product 1

HCID 22254603HCID 22254603, compound

Procedure

The title compound was prepared according to the procedure described in Example 92 substituting isoquinolin-5-ol for methyl 3-hydroxybenzoate. 1H NMR (500 MHz, CDCl3) δ ppm 9.43 (s, 1H), 8.36 (d, 1H), 8.26 (d, 1H), 7.89 (d, 1H), 7.74 (t, 1H), 7.68 (d, 1H), 7.29 (m, 2H), 7.13 (m, 2H), 6.93 (d, 1H), 4.77 (m, 1H), 4.43 (m, 1H), 4.28 (m, 1H), 2.06–2.34 (m, 4H), 1.51 (d, 3H); MS (DCI/NH3) m/z 374 [M+H]+.

Sources & evidence

ORD record
ord-06d4404652d043498ccb154e90b5991f
Source dataset
uspto-grants-2006_01
Patent number
US06989392B2

Reaction notes

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