Ammonia → HCID 10091730, compound

HRID 1611694Notes

Reaction equation

HRID 1611694 reaction equation
[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[OH:12])=[CH:4][CH:3]=[N:2]1.[OH:13][C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=1)[C:17](OC)=O.[NH3:24]>>[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:12][CH2:8][CH2:7][CH2:6][CH:11]([CH3:10])[O:13][C:14]2[CH:23]=[CH:22][CH:21]=[C:16]3[C:15]=2[N:24]=[C:3]([NH2:2])[CH:4]=[CH:17]3)=[CH:4][CH:3]=[N:2]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 88068Methyl 3-HydroxybenzoateHCID 5785062-(5-ISOXAZOLYL)PHENOL

Product 1

HCID 10091730HCID 10091730, compound

Procedure

The title compound was prepared according to the procedure described in Example 92 substituting 2-isoxazol-5-ylphenol for methyl 3-hydroxybenzoate. 1H NMR (500 MHz, CDCl3) δ ppm 8.20 (d, 1H), 7.92 (d, 1H), 7.86 (dd, 1H), 7.34 (m, 1H), 7.23 (t, 1H), 7.16 (dd, 1H), 7.05 (d, 1H), 6.97 (m, 3H), 6.68 (d, 1H), 4.71 (m, 1H), 4.26 (m, 1H), 4.15 (m, 1H), 1.98–2.26 (m, 4H), 1.48 (d, 3H); MS (DCI/NH3) m/z 390 [M+H]+.

Sources & evidence

ORD record
ord-21e8e92c53ef4332af39bb08c7e8ccc3
Source dataset
uspto-grants-2006_01
Patent number
US06989392B2

Reaction notes

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