Diisopropylethylamine → HCID 22254179, compound

Participants

Reaction Conditions

Reaction Steps

To 2-(2,4-dichlorophenyl)-4-fluoro-1-nitrobenzene(32 mgs, 0.1 mmol) in acetonitrile was added 2-(2-aminoethylamino)-5-cyanopyridine (19.2 mgs, 0.1 mmol) and N,N diisopropylethylamine (18 μl, 0.1 mmol), and the mixture was heated to 85° C. over-night. The mixture was partitioned between ethyl acetate and water and the organic layer was dried (MgSO4) and concentrated. Purification on silica gel with 5% methanol in dichloromethane as the eluent yielded 25 mgs of 6-({2-[(2′,4′-dichloro-6-nitro-1,1′-biphenyl-3-yl)amino]ethyl}amino)nicotinonitrile.

Provenance & Evidence