HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 22254171, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- | HCID 83692 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 131725263 | HCID 131725263 | — |
| Product | HCID 22254171 | HCID 22254171 | 93% |
Reaction Steps
To 20 mgs of 6-[(2-{[4-amino-3-(2,4-dichlorophenyl)phenyl]amino}ethyl)-aminopyridine-3-carbonitrile in tetrahydrofuran was added 19 mgs of BOC-sarcosine, 38 mgs of HBTU and 26.2 μl of N,N-diisopropylethylamine, and the mixture was stirred at room temperature over-night. After partitioning the mixture between ethyl acetate and water the organic layer was concentrated. To it was added dichloromethane and TFA to yield 1.2 mgs of 93% pure N˜1˜-[2′,4′-dichloro-5-({2-[(5-cyanopyridin-2-yl)amino]ethyl}amino)-1,1′-biphenyl-2-yl]-N˜2˜-methylglycinamide as the TFA salt after HPLC purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06989382B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-2e3bc016b57a4bf6a1868834d265dbaa |
| Source note | uspto-grants-2006_01 |