Triphenylphosphine → HCID 10482119, compound

Participants

Reaction Conditions

Reaction Steps

DEAD (2.5 eq) and PPh3 (2 eq) were added to N-[4-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-2-(2,4-dichlorophenyl)phenyl]-2-[(2-hydroxyethyl)-methylamino]acetamide (1 eq) dissolved in THF at room temperature. The reaction was heated to 55° C. for 1 hour until completion was determined by LC/MS. The reaction was concentrated and purified by silica column chromatography, eluting with MeOH in CH2Cl2 (5:95, v/v). After collecting the purified fractions and concentrating, 1-[5-({2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino)-2′,4′-dichloro-1,1′-biphenyl-2-yl]-4-methylpiperazin-2-one was attained as a light yellow glass (LC/MS m/z 531.4 MH+) in quantitative yields.

Provenance & Evidence