HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 3,3-Dichloropiperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 2-Piperidone | HCID 12665 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Product | 3,3-Dichloropiperidin-2-one | HCID 322565 | — |
Reaction Steps
Part A. To valerolactam (5.6 g, 55 mmol) in CHCl3 was added PCl5 (34.6 g, 166 mmol) and the reaction was heated to reflux 24 h. The reaction was cooled, quenched with H2O, extracted with CHCl3 and dried (MgSO4) to afford crude 3,3-dichloro-2-piperidinone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06989391B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-c0ec193a29694be8bfb23f1a337fb471 |
| Source note | uspto-grants-2006_01 |