Sulfanilamide → HCID 69012016, compound

HRID 1611852Notes

Reaction equation

HRID 1611852 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5](O)=[O:6].[NH2:24][C:25]1[CH:30]=[CH:29][C:28]([S:31]([NH2:34])(=[O:33])=[O:32])=[CH:27][CH:26]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([CH:20]([CH3:21])[CH3:22])[CH:13]=1)[C:5]([C:29]1[CH:30]=[C:25]([NH2:24])[CH:26]=[CH:27][C:28]=1[S:31]([NH2:34])(=[O:33])=[O:32])=[O:6]

Participants

3

Reactant 2

HCID 5333SulfanilamideHCID 11015728HCID 11015728, compound

Product 1

HCID 69012016HCID 69012016, compoundYield 34.2%

Procedure

3,5-Dibromo-4-(4-methoxy-3-isopropylphenoxy)benzoic acid (0.035 mmol) was coupled with 4-aminobenzenesulphonamide (0.175 mmol) using the method described in Example 58. Purification on HPLC of the residue gave 7 mg (34%) of the title compound.

Workup

  1. customPurification on HPLC of the residue

Sources & evidence

ORD record
ord-ee4b9617c2f749d9b5f1d949f0d0bda4
Source dataset
uspto-grants-2006_01
Patent number
US06989402B1

Reaction notes

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