2-Aminobenzenesulfonamide → HCID 69662889, compound

HRID 1611853Notes

Reaction equation

HRID 1611853 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)C(O)=O.[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31]([NH2:34])(=[O:33])=[O:32]>>[Br:1][C:2]1[CH:3]=[CH:4][CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([CH:20]([CH3:21])[CH3:22])[CH:13]=1.[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31]([NH2:34])(=[O:32])=[O:33]

Participants

3

Reactant 2

HCID 728942-AminobenzenesulfonamideHCID 11015728HCID 11015728, compound

Product 1

HCID 69662889HCID 69662889, compoundYield 56.3%

Procedure

3,5-Dibromo-4-(4-methoxy-3-isopropylphenoxy)benzoic acid (0.035 mmol) was coupled with 2-aminobenzenesulphonamide (0.175 mmol) using the method described in Example 58. Purification on HPLC of the residue gave 11 mg (54%) of the title compound.

Workup

  1. customPurification on HPLC of the residue

Sources & evidence

ORD record
ord-9ae2f80523864117a69ff6fb3a875696
Source dataset
uspto-grants-2006_01
Patent number
US06989402B1

Reaction notes

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