HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(p-Iodophenyl)butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 4-(4-Aminophenyl)butanoic acid | HCID 27049 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Product | 4-(p-Iodophenyl)butyric acid | HCID 4645427 | — |
Reaction Steps
A 5 C mixture of 4(4-aminophenyl)butyric acid (1.0 eq) and aqueous 6N hydrochloric acid (5.44 eq) was treated with 1.05 eq of a 3N aqueous solution of sodium nitrite, adding slowly so as to keep the temperature below 5 C. A solution of 2.8N aqueous potassium iodide (1.01 eq) was added. The reaction was stirred overnight. The layers were separated. The organic phase was purified by flash chromatography using methanol/methylene chloride as eluant to give 4-(4-iodophenyl)butyric acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06991798B1 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-c039557439a04267bec0c67f449a9eaf |
| Source note | uspto-grants-2006_01 |