Hydrochloric Acid → HCID 22251526, compound

Participants

Reaction Steps

61 g of dimethylphenol (0.5 mole), 39 g (0.5 mole) of dimethylsulfoxide (DMSO), and 400 ml of methanol were placed in a 1 liter round bottom flask equipped with a thermometer and a condenser. The mixture was cooled in a liquid nitrogen-isopropyl alcohol bath while hydrogen chloride gas was bubbled in at 10° C. for 6 hours. A precipitate was formed and a part of the methanol was removed by rotavap. The crystals were filtered and washed with ether several times. The solid product gave the following analytical results 1H NMR(Acetone-d6), 2.34 (s, 6H, 2CH3); 3.23 (s, 6H, 2CH3); 7.80 (s, 2H, aromatic).

Provenance & Evidence