Acetic Anhydride → 1,1-Cyclohexanediacetic Anhydride

Participants

Reaction Steps

1,1-Cyclohexanediacetic acid (4 g, 20 mmol) and acetic anhydride (3.8 mL, 40 mmol) were heated under reflux until a clear solution was obtained (˜1 h), and heating continued for a further hour to ensure the reaction had gone to completion. The mixture was cooled to room temperature and the solvent removed in vacuo to afford 1,1-cyclohexanediacetic anhydride (37) (3.6 g, 99% yield). Electrospray mass spectrometry showed the expected molecular ion at m/z=183.2 (M+H+).

Provenance & Evidence