HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpyridine-4-carboxylic acid → N-[4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzooxazol-2-yl]-2-methyl-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpyridine-4-carboxylic acid | HCID 2762821 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzooxazol-2-ylamine | HCID 22252233 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-[4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzooxazol-2-yl]-2-methyl-isonicotinamide | HCID 10338955 | — |
Reaction Steps
From 2-methylisonicotinic acid, HATU and N-diethylisopropylamine in THF, then treatment with 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzooxazol-2-yl-amine in dioxane and DMF. ES-MS m/e (%): 368 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992083B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-e522f48354b74086ad41006403f91637 |
| Source note | uspto-grants-2006_01 |