Diisopropylethylamine → 2-bromo-N-[7-(4-fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-isonicotinamide

Participants

Reaction Steps

To a stirred solution of 203 mg (1.00 mmol) 2-bromo-isonicotinic acid in 5 ml THF were added 442 mg (1.16 mmol) HATU and 0.20 ml (1.16 mmol) N-ethyldiisopropylamine and stirring continued at room temperature for 5 h. A solution of 200 mg (0.77 mmol) 7-(4-fluoro-phenyl)-4-methoxy-benzooxazol-2-yl-amine in 5 ml dioxane and 1 ml DMF was then added and stirring continued at 40° C. for 16 h. The reaction mixture was then poured into 100 ml water and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated in vacuo. Trituration in ether/ethyl acetate (4/1) afforded 233 mg (68%) 2-bromo-N-[7-(4-fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-isonicotinamide as an off-white crystalline solid. ES-MS m/e (%): 444 (M{81Br}+H+, 90), 442 (M{79Br}+H+, 100).

Provenance & Evidence