反应详情

To a stirred solution of 220 mg (0.82 mmol) (4-methoxy-7-nitro-benzooxazol-2-yl)-carbamic acid methyl ester in 25 ml methanol and 45 ml dichloromethane was added a spatula end of 10% palladium on charcoal and stirring continued for 18 h at room temperature under an atmosphere of hydrogen. The mixture was then filtered and the filtrate concentrated in vacuo. Flash chromatography (2/98 methanol/dichloromethane) afforded 114 mg (58%) (7-amino-4-methoxy-benzooxazol-2-yl)-carbamic acid methyl ester as a white crystalline solid. ES-MS m/e (%): 238 (M+H+, 100).

1. filtrationThe mixture was then filtered
2. concentrationthe filtrate concentrated in vacuo