反应详情

To an ethanol (24 mL) slurry of 2-{6-[(5-chloro-1H-indole-2-carbonyl)-amino]-5-ethoxy-pyridin-3-yl}-2-hydroxy-propionic acid ethyl ester (1.2 g) was added 1N NaOH, and the reaction mixture was shaken for 1 hr. The reaction mixture was filtered, the filtrate was acidified with 1N HCl, and then evaporated to yield 190 mg of the title compound. LC/MS+=404.

1. filtrationThe reaction mixture was filtered
2. customevaporated