3,4,5-Trimethoxyaniline → HCID 22252397, compound

Participants

Reaction Steps

1.2 g of the compound obtained in Step B, 1.05 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 0.92 g of 3,4,5-trimethoxyaniline in solution in 50 ml of dichloromethane and 1.75 ml of diisopropylethylamine are stirred, under argon, for 24 hours at room temperature. The reaction mixture is washed with 50 ml of water, decanted, dried over Na2SO4 and concentrated under a partial vacuum. The hydrochloride is then prepared in 20 ml of ethanol and 2 ml of an ethereal hydrogen chloride solution, enabling the expected product to be obtained.

Provenance & Evidence