Methyl iodide → HCID 22252348, compound

Participants

Reaction Steps

0.9 g of the compound obtained in Example 2 is dissolved in 50 ml of tetrahydrofuran and, under argon, there are added 0.265 g of potassium tert-butoxide and then, after 1 hour's stirring, 0.15 ml of methyl iodide. Stirring is maintained for 1 hour and the solvent is removed in vacuo. The residue is taken up in a mixture of water/dichloromethane, extracted, decanted and then dried over Na2SO4 and evaporated to dryness in vacuo. The product is converted to the hydrochloride using ethanolic hydrogen chloride.

Provenance & Evidence