HCID 22252387, compound → HCID 17908971, compound

HRID 1611994Notes

Reaction equation

HRID 1611994 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]>[OH-].[Na+].CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 1

HCID 22252387HCID 22252387, compound

Product 1

HCID 17908971HCID 17908971, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of 1.6 g of the compound obtained in Step B in 25 ml of 1M sodium hydroxide solution and 25 ml of methanol is stirred for 4 hours at 50° C., and then distilled under a partial vacuum, rendered acidic with 25 ml of 1M hydrochloric acid and extracted with dichloromethane. The combined organic phases are dried over sodium sulphate and then evaporated to dryness, enabling the expected product to be isolated.

Workup

  1. distillationdistilled under a partial vacuum
  2. extractionextracted with dichloromethane
  3. dry with materialThe combined organic phases are dried over sodium sulphate
  4. customevaporated to dryness
  5. customto be isolated

Sources & evidence

ORD record
ord-2d0bd39109c84966a78584a5e6b61691
Source dataset
uspto-grants-2006_01
Patent number
US06992085B2

Reaction notes

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