HCID 23594025, compound → HCID 23594011, compound

Participants

Reaction Steps

A solution of 2-(1-methoxy-5,6,7,8-tetrahydronaphthalen-2-yl)-3-nitrobenzoic acid, methyl ester, (0.5 g, 1.46 mM) in triphenyl phosphite (2.26 g, 1.91 mL, 7.29 mM) was heated at 160° C. for 48 h under a nitrogen atmosphere. The mixture was cooled to room temperature and dried azeotropically in vacuo with toluene, then purified by column chromatography on silica gel (elution with 10% ethyl acetate/hexane) to afford 0.2 g (44%) of the title compound 11-methoxy-7,8,9,10-tetrahydro-5H-benzo[b]carbazole-1-carboxylic acid, methyl ester as a tan solid (MP 194–196° C., MW 309.37).

Provenance & Evidence