Ethyl isocyanate → HCID 178465351, compound

HRID 16121Notes

Reaction equation

HRID 16121 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C@H:17]2[CH2:22][CH2:21][C@H:20]([NH2:23])[CH2:19][CH2:18]2)[CH2:11][CH2:10]1.[CH2:24]([N:26]=[C:27]=[O:28])[CH3:25]>ClCCl>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C@H:17]2[CH2:22][CH2:21][C@H:20]([NH:23][C:27]([NH:26][CH2:24][CH3:25])=[O:28])[CH2:19][CH2:18]2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 178511523HCID 178511523, compound

Product 1

HCID 178465351HCID 178465351, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.56 g (1.2 mmol) trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-cyclohexyl-amine was dissolved in dry dichloromethane (20 ml), ethylisocyanate (0.1 ml, 1.3 mmol) was added and the reaction mixture was stirred at room temperature for 4 hours. The solvent was removed in vacuo. The residue was stirred with water, the precipitate was filtered, giving the title compound (0.33 g, 65%). Melting point: 235-8° C.

Workup

  1. customThe solvent was removed in vacuo
  2. stirringThe residue was stirred with water
  3. filtrationthe precipitate was filtered

Sources & evidence

ORD record
ord-aaf101952fc04af99b733d8722fd1963
Source dataset
uspto-grants-2010_06
Patent number
US07737142B2

Reaction notes

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