Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Dimethoxybenzeneboronic acid → (1R,2S)-1-{[5-(2,4-dimethoxyphenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Dimethoxybenzeneboronic acid | HCID 2734341 | — |
| 반응물 | (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol | HCID 58583246 | — |
| 생성물 | (1R,2S)-1-{[5-(2,4-dimethoxyphenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol | HCID 58583448 | — |
반응 단계
Following the procedure for the preparation of (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol but substituting 2,4-dimethoxyphenylboronic acid and making non-critical variations provided the title compound as an off-white foam. IR (diffuse reflectance) 2966, 2934, 1610, 1567, 1483, 1391, 1303, 1280, 1253, 1208, 1159, 1128, 1046, 1034, 741 cm−1; OAMS supporting ions at: ESI+ 420.1; MS (EI) m/z 419 (M+); HRMS (FAB) calcd for C25H29N3O3+H1 420.2287, found 420.2278.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06992087B2 |
| 출처 데이터셋 | uspto-grants-2006_01 |
| ORD ID | ord-b52ebaeac09b48f0a4b4614cebaab894 |
| 출처 메모 | uspto-grants-2006_01 |