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1-Isoquinolinamine → N-[5-(2,4-dichlorophenyl)-3,6-dimethylpyrazin-2-yl]isoquinolin-1-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Isoquinolinamine | HCID 73742 | — |
| 反応物 | 2-Bromo-5-(2,4-dichlorophenyl)-3,6-dimethylpyrazine | HCID 22147425 | — |
| 反応物 | (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol | HCID 58583341 | — |
| 生成物 | N-[5-(2,4-dichlorophenyl)-3,6-dimethylpyrazin-2-yl]isoquinolin-1-amine | HCID 22147487 | — |
反応手順
Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 2-bromo-5-(2,4-dichlorophenyl)-3,6-dimethylpyrazine and isoquinolin-1-amine, and making non-critical variations provided the title compound as a oil: 1H NMR (CDCl3) δ 2.36, 2.93, 6.75, 7.38, 7.53, 7.57, 8.96; HRMS (ESI+) calcd for C21H16Cl2N4 (M+H)+ 395.0830, found 395.0821.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06992087B2 |
| 出典データセット | uspto-grants-2006_01 |
| ORD ID | ord-f24124c2bb7d406dac1818f44fe4593c |
| 出典メモ | uspto-grants-2006_01 |