HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethyl-6-methylpyridin-2-amine → 5-(2,4-dichlorophenyl)-3,6-diethyl-N-(3-ethyl-6-methylpyridin-2-yl)pyrazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethyl-6-methylpyridin-2-amine | HCID 3016311 | — |
| Reactant | 2-Bromo-5-(2,4-dichlorophenyl)-3,6-diethylpyrazine | HCID 22147437 | — |
| Reactant | (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol | HCID 58583341 | — |
| Product | 5-(2,4-dichlorophenyl)-3,6-diethyl-N-(3-ethyl-6-methylpyridin-2-yl)pyrazin-2-amine | HCID 10287773 | — |
Reaction Steps
Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 2-bromo-5-(2,4-dichlorophenyl)-3,6-diethylpyrazine and 3-ethyl-6-methylpyridin-2-amine, and making non-critical variations provided the title compound as a oil: 1H NMR (DMSO-d6) δ 0.95, 1.15, 2.33, 2.31, 2.51, 2.70, 6.95, 7.51, 7.75, 8.57; HRMS (ESI+) calcd for C22H24Cl2N4 (M+H)+ 415.1456, found 415.1442.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992087B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-bb5a953b540144c49ec276b33e6e5e11 |
| Source note | uspto-grants-2006_01 |