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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 161216Generated: October 27, 2026

Diisobutylaluminum hydride → N-(3-{2-[8-(aminomethyl)-1,4-dioxaspiro[4.5]dec-8-yl]-1,3-thiazol-5-yl}-5-methylphenyl)-4-(trifluoromethyl)pyrimidin-2-amine

https://huagongshe.com/reaction/161216

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisobutylaluminum hydrideHCID 14487—
ReactantHydrideHCID 166653—
ReactantBis(2-methylpropyl)alumanyliumHCID 16686348—
Reactant8-[5-(3-Methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-dioxaspiro[4.5]decane-8-carbonitrileHCID 67261700—
ProductN-(3-{2-[8-(aminomethyl)-1,4-dioxaspiro[4.5]dec-8-yl]-1,3-thiazol-5-yl}-5-methylphenyl)-4-(trifluoromethyl)pyrimidin-2-amineHCID 67429575—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-0f7d677d36fe4529a50e3c27f75de82e
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)