N-(3,4-dihydro-2H-chromen-4-yl)-3,6-diethylpyrazin-2-amine → 5-bromo-N-(3,4-dihydro-2H-chromen-4-yl)-3,6-diethylpyrazin-2-amine

Participants

Reaction Steps

Following the procedure for the preparation of (1R,2S)-1-[(5-bromo-3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting N-(3,4-dihydro-2H-chromen-4-yl)-3,6-diethylpyrazin-2-amine and making non-critical variations provided the title compound as a oil: 1H NMR (300 MHz, CDCl3) δ) 7.28-7.21, 6.96-6.89, 5.26, 4.54, 4.29-4.22, 2.84, 2.57, 2.22, 1.32-1.24; HRMS (FAB) calcd for C17H20BrN3O+H 362.0868, found 362.0861. Anal. Calcd for C17H20BrN3O: C, 56.36; H, 5.56; N, 11.60. Found: C, 56.10; H, 5.56; N, 11.35.

Provenance & Evidence