3-Chloro-2,5-dimethylpyrazine → HCID 58583441, compound

HRID 1612221Notes

Reaction equation

HRID 1612221 reaction equation
[CH2:1]([C:3]1[C:4]([NH:11][C@@H:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][C@@H:13]2[OH:21])=[N:5][C:6]([CH2:9]C)=[CH:7][N:8]=1)C.ClC1C(C)=NC=C(C)N=1>>[CH3:1][C:3]1[C:4]([NH:11][C@@H:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][C@@H:13]2[OH:21])=[N:5][C:6]([CH3:9])=[CH:7][N:8]=1

Participants

3

Reactant 2

HCID 667713-Chloro-2,5-dimethylpyrazineHCID 58583341(1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

Product 1

HCID 58583441HCID 58583441, compound

Procedure

Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 3-chloro-2,5-dimethylpyrazine and making non-critical variations provided the title compound as a oil: 1H NMR (300 MHz, CDCl3) δ) 7.68, 7.32-7.28, 5.59, 4.80, 3.27, 3.09, 2.92, 2.38; HRMS (FAB) calcd for C15H17N3O+H 256.1450, found 256.1460.

Sources & evidence

ORD record
ord-1a59144958cf432b8bab3c1391e0c599
Source dataset
uspto-grants-2006_01
Patent number
US06992087B2

Reaction notes

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