HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine → 3,6-diethyl-N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine | HCID 22147356 | — |
| Reactant | (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol | HCID 58583341 | — |
| Product | 3,6-diethyl-N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine | HCID 22147316 | — |
Reaction Steps
Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 8-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine and making non-critical variations provided the title compound as a oil: 1H NMR (300 MHz, CDCl3) δ) 7.63, 7.22, 6.78, 5.40, 4.31, 3.71, 2.86-2.65, 2.53-2.38, 1.88-1.67, 1.32, 1.21; HRMS (FAB) calcd for C19H25N3O+H 312.2076, found 312.2077.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992087B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-f2c678bc27384015abb6ec5a3a13d1f5 |
| Source note | uspto-grants-2006_01 |