反应详情

Following the procedure for the preparation of (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol but substituting 5-bromo-3,6-diethyl-N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine, ethylene glycol dimethyl ether and tetrakis(triphenylphosphine) palladium and making non-critical variations provided the title compound as a oil: 1H NMR (300 MHz, CDCl3) δ) 7.50, 7.34-7.22, 6.83, 5.46, 4.45, 3.75, 2.94-2.79, 2.60-2.53, 1.92-1.77, 1.28-1.16; HRMS (FAB) calcd for C25H27Cl2N3O+H 456.1609, found 456.1602.