5H,6H,7H-cyclopenta[b]pyridin-7-one → 6,7-dihydro-5H-cyclopenta(b)pyridin-7-amine

HRID 1612245Notes

Reaction equation

HRID 1612245 reaction equation
O1[C:5]2[CH2:6][CH2:7][CH2:8][CH:9]([NH2:10])[C:4]=2[CH:3]=[CH:2]1.[N:11]1C=CC=C2CCC(=O)C=12>>[N:10]1[CH:9]=[CH:8][CH:7]=[C:6]2[CH2:5][CH2:4][CH:3]([NH2:11])[C:2]=12

Participants

3

Reactant 2

HCID 110407455H,6H,7H-cyclopenta[b]pyridin-7-oneHCID 185251714,5,6,7-Tetrahydro-1-benzofuran-4-amine

Product 1

HCID 120990656,7-dihydro-5H-cyclopenta(b)pyridin-7-amine

Procedure

Following the procedure for the preparation of 4,5,6,7-tetrahydro-1-benzofuran-4-amine but 5,6-dihydro-7H-cyclopenta[b]pyridin-7-one and making non-critical variations provided the title compound as a oil: 1H NMR (300 MHz, DMSO) δ) 8.49, 7.79, 7.36, 4.65, 3.38, 3.01-2.90, 2.55, 1.93; (MS/CI) calcd for C8H10N2+H 135.2, found 135.2.

Sources & evidence

ORD record
ord-13754e4083c249eeba1f0b55e9b26664
Source dataset
uspto-grants-2006_01
Patent number
US06992087B2

Reaction notes

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