HRID1612269

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58583246

未命名化合物

HCID58583493

未命名化合物

PRODUCTS

产物

HCID58583410

未命名化合物

PROCEDURE

实验过程

Following the procedure for the preparation of (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol but substituting benzyl (trans)-3-[(5-bromo-3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate and making non-critical variations provided the title compound as a oil: 1H NMR (300 MHz, CDCl3) δ) 7.49-7.11, 5.97, 5.17, 4.78, 4.67, 4.33-4.26, 4.16-3.96, 3.46, 2.69, 2.49, 1.46-1.24, 1.14; HRMS (FAB) calcd for C26H28Cl2N4O3+H 515.1616, found 515.1606.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-bc86ea3123434673962ba8e07a8ffc3f
来源数据集: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06992087B2
来源说明: uspto-grants-2006_01

反应SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([CH2:28][CH3:29])[C:12]([NH:17][C@@H:18]2C3C(=CC=CC=3)[CH2:20][C@@H:19]2[OH:27])=[N:13][C:14]=1[CH2:15][CH3:16].BrC1N=C(CC)C(N[C@H]2[C@H](O)C[N:42]([C:46]([O:48][CH2:49][C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)=[O:47])[CH2:41]2)=NC=1CC>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([CH2:28][CH3:29])[C:12]([NH:17][C@H:18]2[C@H:19]([OH:27])[CH2:20][N:42]([C:46]([O:48][CH2:49][C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)=[O:47])[CH2:41]2)=[N:13][C:14]=1[CH2:15][CH3:16]