2-Methyl-1-pyrrolidin-2-ylmethyl-pyrrolidine → [2-Fluoro-4-[(4-methylsulfonylphenyl)methoxy]phenyl]-[2-[(2-methylpyrrolidin-1-yl)methyl]pyrrolidin-1-yl]methanone

HRID 161231Notes

Reaction equation

HRID 161231 reaction equation
[CH3:1][O:2][C:3]([c:4]1[c:5]([F:22])[cH:6][c:7]([O:10][CH2:11][c:12]2[cH:13][cH:14][c:15]([S:18](=[O:19])(=[O:20])[CH3:21])[cH:16][cH:17]2)[cH:8][cH:9]1)=[O:23].[CH3:24][CH:25]1[N:26]([CH2:30][CH:31]2[NH:32][CH2:33][CH2:34][CH2:35]2)[CH2:27][CH2:28][CH2:29]1>>[C:3]([c:4]1[c:5]([F:22])[cH:6][c:7]([O:10][CH2:11][c:12]2[cH:13][cH:14][c:15]([S:18](=[O:19])(=[O:20])[CH3:21])[cH:16][cH:17]2)[cH:8][cH:9]1)(=[O:23])[N:32]1[CH:31]([CH2:30][N:26]2[CH:25]([CH3:24])[CH2:29][CH2:28][CH2:27]2)[CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 205810162-Methyl-1-pyrrolidin-2-ylmethyl-pyrrolidineHCID 576851252-Fluoro-4-(4-methanesulfonyl-benzyloxy)-benzoic Acid Methyl Ester

Product 1

HCID 11641420[2-Fluoro-4-[(4-methylsulfonylphenyl)methoxy]phenyl]-[2-[(2-methylpyrrolidin-1-yl)methyl]pyrrolidin-1-yl]methanone

Sources & evidence

ORD record
ord-e712c0658f394cdbb63bebe5f704ede5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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