5-(2,4-dichlorophenyl)-N-[(1R,2S)-2-ethoxy-2,3-dihydro-1H-inden-1-yl]-3,6-diethylpyrazin-2-amine → cis-(+/-)-5-(2-chloro-4-methoxyphenyl)-N-[4-ethoxytetrahydrofuran-3-yl]-3,6-diethylpyrazin-2-amine

Participants

Role	Name	HCID	Charge
Reactant	5-(2,4-dichlorophenyl)-N-[(1R,2S)-2-ethoxy-2,3-dihydro-1H-inden-1-yl]-3,6-diethylpyrazin-2-amine	HCID 10217073	—
Reactant	cis-(+/-)-4-{[5-(2-Chloro-4-methoxyphenyl)-3,6-diethylpyrazin-2-yl]amino}tetrahydrofuran-3-ol	HCID 86588878	—
Product	cis-(+/-)-5-(2-chloro-4-methoxyphenyl)-N-[4-ethoxytetrahydrofuran-3-yl]-3,6-diethylpyrazin-2-amine	HCID 58583371	—

Reaction Steps

Following the procedure for the preparation of 5-(2,4-dichlorophenyl)-N-[(1R,2S)-2-ethoxy-2,3-dihydro-1H-inden-1-yl]-3,6-diethylpyrazin-2-amine but substituting of cis-(+/−)-4-{[5-(2-chloro-4-methoxyphenyl)-3,6-diethylpyrazin-2-yl]amino}tetrahydrofuran-3-ol and making non-critical variations provided the title compound as a light yellow oil. IR (liq.) 2973, 2936, 2874, 1606, 1566, 1481, 1441, 1396, 1287, 1230, 1203, 1181, 1124, 1078, 1046 cm−1; OAMS supporting ions at: ESI+ 406.2; MS (EI) m/z 405 (M+); HRMS (FAB) calcd for C21H28CLN3O3+H1 406.1897, found 406.1889.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06992087B2
Source dataset	uspto-grants-2006_01
ORD ID	ord-1399b16bdc584fe487a4c61856df5354
Source note	uspto-grants-2006_01