HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(((Tert-butoxy)carbonyl)amino)butanoic acid → methyl N-{2-[(tert-butoxycarbonyl)amino]butanoyl}alaninate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(((Tert-butoxy)carbonyl)amino)butanoic acid | HCID 333522 | — |
| Reactant | Methyl 2-aminobutanoate hydrochloride | HCID 13283515 | — |
| Reactant | methyl{[N-(tert-butoxycarbonyl)-L-alanyl]amino}(cyclopropyl)acetate | HCID 58583288 | — |
| Product | methyl N-{2-[(tert-butoxycarbonyl)amino]butanoyl}alaninate | HCID 86588879 | — |
Reaction Steps
Following the procedure for the preparation of methyl {[N-(tert-butoxycarbonyl)-L-alanyl]amino}(cyclopropyl)acetate but substituting N-Boc-alpha-aminobutyric acid and methyl 2-aminobutanoate hydrochloride and making non-critical variations provided the title compound as a solid: 1H NMR (CDCl3) δ 0.82-0.91, 1.24-1.38, 1.52, 1.68-2.05, 3.75, 4.20, 4.52-4.59, 5.05, 6.69.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992087B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-643426b83b8640e6a0b606db6d9fbba1 |
| Source note | uspto-grants-2006_01 |