HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | methyl{[N-(tert-butoxycarbonyl)-L-alanyl]amino}(cyclopropyl)acetate | HCID 58583288 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride | HCID 86588880 | 100% |
Reaction Steps
A solution of methyl {[N-(tert-butoxycarbonyl)-L-alanyl]amino}(cyclopropyl)-acetate (72 mg, 0.24 mmol) in 4 N HCl in dioxane (1 mL) was stirred at rt for 45 min. Concentrate to afford 57 mg (100%) of methyl (L-alanylamino)(cyclopropyl)acetate hydrochloride as a solid: 1H NMR (DMSO-d6) δ 0.42-0.60, 1.21-1.26, 1.68, 3.65-3.91, 4.60, 8.17; MS (ESI+) for C8H12N2O2 m/z 201 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992087B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-e9f0be14e90c4eed89b5ec59357f14c1 |
| Source note | uspto-grants-2006_01 |