Methyl({2-[(tert-butoxycarbonyl)amino]butanoyl}amino)(cyclopropyl)acetate → Methyl[(2-aminobutanoyl)amino](cyclopropyl)acetate hydrochloride

HRID 1612321Notes

Reaction equation

HRID 1612321 reaction equation
[ClH:1].N[C@H](C(NC(C1CC1)C(OC)=O)=O)C.C(OC([NH:23][CH:24]([CH2:36][CH3:37])[C:25]([NH:27][CH:28]([CH:33]1[CH2:35][CH2:34]1)[C:29]([O:31][CH3:32])=[O:30])=[O:26])=O)(C)(C)C>>[ClH:1].[NH2:23][CH:24]([CH2:36][CH3:37])[C:25]([NH:27][CH:28]([CH:33]1[CH2:35][CH2:34]1)[C:29]([O:31][CH3:32])=[O:30])=[O:26]

Participants

3

Reactant 2

HCID 23593721Methyl({2-[(tert-butoxycarbonyl)amino]butanoyl}amino)(cyclopropyl)acetateHCID 86588880methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride

Product 1

HCID 86588881Methyl[(2-aminobutanoyl)amino](cyclopropyl)acetate hydrochloride

Procedure

Following the procedure for the preparation of methyl (L-alanylamino)(cyclopropyl)acetate hydrochloride but substituting methyl ({2-[(tert-butoxycarbonyl)amino]butanoyl}amino)(cyclopropyl)acetate and making non-critical variations provided the title compound as a solid: 1H NMR (DMSO-d6) δ 0.29-0.40, 0.88-0.94, 1.12, 1.37, 1.75-1.82, 3.57, 3.62-3.79, 8.29.

Sources & evidence

ORD record
ord-48a978037ebc43b1bde96100e043398b
Source dataset
uspto-grants-2006_01
Patent number
US06992087B2

Reaction notes

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