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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1612325Generated: November 3, 2026

3-Cyclopropyl-6-methylpiperazine-2,5-dione → 3-Ethyl-6-methylpiperazine-2,5-dione

https://huagongshe.com/reaction/1612325

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Cyclopropyl-6-methylpiperazine-2,5-dioneHCID 22147368—
Reactantmethyl N-(2-aminobutanoyl)alaninate hydrochlorideHCID 86588882—
Product3-Ethyl-6-methylpiperazine-2,5-dioneHCID 22147409—

Reaction Steps

Following the procedure for the preparation of 3-cyclopropyl-6-methylpiperazine-2,5-dione but substituting methyl N-(2-aminobutanoyl)alaninate hydrochloride and making non-critical variations provided the title compound as a solid: 1H NMR (DMSO-d6) δ 0.81-0.86, 1.25-1.27, 1.64-1.76, 3.73-3.91, 7.37, 8.07-8.15.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06992087B2
Source datasetuspto-grants-2006_01
ORD IDord-a1c3e7adc1b740b2ad586dbd5b6bc112
Source noteuspto-grants-2006_01