HCID 22147219, compound → HCID 58583498, compound

HRID 1612333Notes

Reaction equation

HRID 1612333 reaction equation
[CH2:1]([C:3]1[C:4]([NH:11][C@@H:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][C@@H:13]2[OH:21])=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2].Cl[C:23]1C(C2CC2)=NC=C(CC)N=1>>[CH:1]1([C:3]2[C:4]([NH:11][C@@H:12]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH2:14][C@@H:13]3[OH:21])=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=2)[CH2:23][CH2:2]1

Participants

3

Reactant 2

HCID 22147219HCID 22147219, compoundHCID 58583341(1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

Product 1

HCID 58583498HCID 58583498, compound

Procedure

Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 3-chloro-2-cyclopropyl-5-ethylpyrazine and making non-critical variations provided the title compound as a solid: 1H NMR (CDCl3) δ 0.93-1.02, 1.24-1.30, 1.72-1.81, 2.61-2.68, 3.06-3.30, 4.79-4.84, 5.36, 5.58, 7.24-7.35, 7.66; MS (ESI+) for C18H21N3O m/z 296 (M+H)+.

Sources & evidence

ORD record
ord-75b0d5b5515e46aca577e1dc91a9949e
Source dataset
uspto-grants-2006_01
Patent number
US06992087B2

Reaction notes

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