HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1,3-Dihydro-α,α-dimethyl-1,3-dioxo-2H-isoindole-2-acetic acid | HCID 774369 | — |
| Product | 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-propionyl chloride | HCID 22253322 | 98.3% |
Reaction Steps
Thionyl chloride (750 ml, 10.28 mol) was added to 2-methyl-2-phthalimidopropanoic acid (385 g, 1.65 mol) and the mixture refluxed under nitrogen for 3 hours. Excess thionyl chloride was removed under reduced pressure to yield a solid. The solid was washed with diethyl ether (2×250 ml) to yield the title compound as a white crystalline solid (408.2 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992184B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-7001b59a8c114939800b4dc7f32e6763 |
| Source note | uspto-grants-2006_01 |