HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitro-5-(2-oxopyrrolidin-1-yl)benzoic acid → 3-Amino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitro-5-(2-oxopyrrolidin-1-yl)benzoic acid | HCID 22253023 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid | HCID 22252990 | 107.3% |
Reaction Steps
A mixture of 3-nitro-5-(2-oxopyrrolidin-1-yl)-benzoic acid (D5) (2.86 g) and 10% Pd—C (0.7 g) in methanol (450 ml) water (50 ml) was hydrogenated at atmospheric pressure for 3 hrs. The mixture was filtered through Celite and concentrated to give 3-amino-5-(2-oxopyrrolidin-1-yl)-benzoic acid (2.70 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992103B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-e5e74262b62e4c76ae517cbf2580bf74 |
| Source note | uspto-grants-2006_01 |