2-(Benzyloxy) ethanol → HCID 22253029, compound

HRID 1612439Notes

Reaction equation

HRID 1612439 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:17]([O:24]CCO)[C:18]1C=CC=CC=1>>[OH:24][CH2:17][CH2:18][O:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:10]=1)[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 121412-(Benzyloxy) ethanolHCID 222530273-Hydroxy-5-(2-oxopyrrolidin-1-yl)benzoic acid

Product 1

HCID 22253029HCID 22253029, compound

Procedure

Prepared from the methyl ester of 3-hydroxy-5-(2-oxopyrrolidin-1-yl)benzoic acid (D6) by Mitsunobu reaction with 2-benzyloxyethanol, followed by saponification of the methyl ester and hydrogenolytic removal of the benzyl group.

Workup

  1. customfollowed by saponification of the methyl ester and hydrogenolytic removal of the benzyl group

Sources & evidence

ORD record
ord-8281905f679349acb6d3dd30a419a409
Source dataset
uspto-grants-2006_01
Patent number
US06992103B2

Reaction notes

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