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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1612440Generated: October 30, 2026

3-Bromo-5-methoxybenzoic acid → N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-bromo-5-methoxybenzamide

https://huagongshe.com/reaction/1612440

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromo-5-methoxybenzoic acidHCID 4060048—
Reactant(2R,4S,5S)-5-Amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amideHCID 68889549—
ReactantN-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-bromo-4-fluorobenzamideHCID 69589710—
ProductN-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-bromo-5-methoxybenzamideHCID 69589673—

Reaction Steps

Prepared as for D3 from (2R,4S,5S)-5-amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amide (D29) and 3-bromo-5-methoxybenzoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06992103B2
Source datasetuspto-grants-2006_01
ORD IDord-db069cfd24924ed1974cfe58c55d1a70
Source noteuspto-grants-2006_01