3,5-bis(2-oxopyrrolidin-1-yl)benzoic Acid → 2-Fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzoic Acid

HRID 1612451Notes

Reaction equation

HRID 1612451 reaction equation
O=C1CCCN1C1C=C(C=C(N2CCCC2=O)C=1)C(O)=O.[F:22][C:23]1[C:32]([N:33]2[CH2:37][CH2:36][CH2:35][C:34]2=[O:38])=[CH:31][C:30]([N:39]2[CH2:43][CH2:42][CH2:41][C:40]2=[O:44])=[CH:29][C:24]=1[C:25]([O:27]C)=[O:26]>>[F:22][C:23]1[C:32]([N:33]2[CH2:37][CH2:36][CH2:35][C:34]2=[O:38])=[CH:31][C:30]([N:39]2[CH2:43][CH2:42][CH2:41][C:40]2=[O:44])=[CH:29][C:24]=1[C:25]([OH:27])=[O:26]

Participants

3

Reactant 2

HCID 111620233,5-bis(2-oxopyrrolidin-1-yl)benzoic AcidHCID 22253009Methyl 2-fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzoate

Product 1

HCID 222530082-Fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzoic Acid

Procedure

Prepared in an analogous manner to D8 from methyl 2-fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzoate (D39).

Sources & evidence

ORD record
ord-573bd6c6b02f4cc99760d9b06b8db401
Source dataset
uspto-grants-2006_01
Patent number
US06992103B2

Reaction notes

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