Cyclobutanol → Methyl 3-cyclobutyloxy-5-(2-oxopyrrolidin-1-yl)benzoate

HRID 1612454Notes

Reaction equation

HRID 1612454 reaction equation
[CH:1]1([OH:5])[CH2:4][CH2:3][CH2:2]1.O[C:7]1[CH:8]=[C:9]([CH:14]=[C:15]([N:17]2[CH2:21][CH2:20][CH2:19][C:18]2=[O:22])[CH:16]=1)[C:10]([O:12][CH3:13])=[O:11]>>[CH:1]1([O:5][C:7]2[CH:8]=[C:9]([CH:14]=[C:15]([N:17]3[CH2:21][CH2:20][CH2:19][C:18]3=[O:22])[CH:16]=2)[C:10]([O:12][CH3:13])=[O:11])[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 76218CyclobutanolHCID 22252977Methyl 3-hydroxy-5-(2-oxopyrrolidin-1-yl)benzoate

Product 1

HCID 22252979Methyl 3-cyclobutyloxy-5-(2-oxopyrrolidin-1-yl)benzoate

Procedure

Prepared in an analogous manner to D14 (first part of synthesis) from cyclobutanol and methyl 3-hydroxy-5-(2-oxopyrrolidin-1-yl)-benzoate (D41).

Sources & evidence

ORD record
ord-807570546b5e42afa5808d78dc889e4e
Source dataset
uspto-grants-2006_01
Patent number
US06992103B2

Reaction notes

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