2-Fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzoic Acid → 2-Fluoro-N-[(S)-1-((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)-2-phenylethyl]-3,5-bis-(2-oxopyrrolidin-1-yl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzoic Acid	HCID 22253008	—
Reactant	(3R,5S)-5-((S)-1-Amino-2-phenylethyl)-3-methyldihydrofuran-2-one	HCID 68679802	—
Reactant	N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-bromo-4-fluorobenzamide	HCID 69589710	—
Product	2-Fluoro-N-[(S)-1-((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)-2-phenylethyl]-3,5-bis-(2-oxopyrrolidin-1-yl)benzamide	HCID 69589694	—

Reaction Steps

Prepared in an analogous manner to D3 from 2-fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzoic acid (D40) and (3R,5S)-5-((S)-1-amino-2-phenylethyl)-3-methyldihydrofuran-2-one (D48).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06992103B2
Source dataset	uspto-grants-2006_01
ORD ID	ord-7d61d87b7e7e4ebebce8783236b6d92e
Source note	uspto-grants-2006_01