HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethyl-butylcarbamoyl)-2-hydroxypenty]-3,5-bis-(2-oxo-pyrrolidin-1-yl)benzamide → 3-Acetylamino-N-[(1S,2S,4R)-1-benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]-5-(2-oxopyrrolidin-1-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethyl-butylcarbamoyl)-2-hydroxypenty]-3,5-bis-(2-oxo-pyrrolidin-1-yl)benzamide | HCID 10196800 | — |
| Reactant | 3-Acetylamino-5-(2-oxopyrrolidin-1-yl)benzoic acid | HCID 22253004 | — |
| Reactant | (2R,4S,5S)-5-Amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amide | HCID 68889549 | — |
| Product | 3-Acetylamino-N-[(1S,2S,4R)-1-benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]-5-(2-oxopyrrolidin-1-yl)benzamide | HCID 58583653 | — |
Reaction Steps
Prepared in an analogous manner to E5, from 3-acetylamino-5-(2-oxopyrrolidin-1-yl)benzoic acid (D13) and (2R,4S,5S)-5-amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amide (D29).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992103B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-54002531340d4de4ade441ef0eea9fb1 |
| Source note | uspto-grants-2006_01 |