Isobutylamine → N-[(1S,2S,4R)-1-Benzyl-4-(isobutylcarbamoyl)-2-hydroxypentyl]-3-isopropoxy-5-(2-oxopyrrolidin-1-yl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	Isobutylamine	HCID 6558	—
Reactant	[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-carbamic acid t-butyl ester	HCID 69507916	—
Reactant	3-Isopropoxy-N-[(S)-1-((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)-2-phenylethyl]-5-(2-oxopyrrolidin-1-yl)benzamide	HCID 69589765	—
Product	N-[(1S,2S,4R)-1-Benzyl-4-(isobutylcarbamoyl)-2-hydroxypentyl]-3-isopropoxy-5-(2-oxopyrrolidin-1-yl)benzamide	HCID 10218221	—

Reaction Steps

Prepared in an analogous manner to D1 from isobutylamine and 3-isopropoxy-N-[(S)-1-((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)-2-phenylethyl]-5-(2-oxopyrrolidin-1-yl)benzamide (D49).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06992103B2
Source dataset	uspto-grants-2006_01
ORD ID	ord-c2e496e209794a48919473c60e5e1acf
Source note	uspto-grants-2006_01