HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Dimethylcyclohexan-1-amine → N-[(1S,2S,4R)-1-Benzyl-4-(4,4-dimethylcyclohexylcarbamoyl)-2-hydroxypentyl]-3-isopropoxy-5-(2-oxopyrrolidin-1-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Dimethylcyclohexan-1-amine | HCID 421054 | — |
| Reactant | [(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-carbamic acid t-butyl ester | HCID 69507916 | — |
| Reactant | 3-Isopropoxy-N-[(S)-1-((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)-2-phenylethyl]-5-(2-oxopyrrolidin-1-yl)benzamide | HCID 69589765 | — |
| Product | N-[(1S,2S,4R)-1-Benzyl-4-(4,4-dimethylcyclohexylcarbamoyl)-2-hydroxypentyl]-3-isopropoxy-5-(2-oxopyrrolidin-1-yl)benzamide | HCID 10312223 | — |
Reaction Steps
Prepared in an analogous manner to D1 from 4,4-dimethylcyclohexylamine (D53) and 3-isopropoxy-N-[(S)-1-((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)-2-phenylethyl]-5-(2-oxopyrrolidin-1-yl)benzamide (D49).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992103B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-1656c004f8794ba6bf499aaab6a7e2ef |
| Source note | uspto-grants-2006_01 |