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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1612501Generated: November 1, 2026

3-Hydroxy-5-(2-oxopyrrolidin-1-yl)benzoic acid → N-[(1S,2S,4R)-1-Benzyl-4-(2-cyclohexylethylcarbamoyl)-2-hydroxypentyl]-3-isopropoxy-5-(2-oxopyrrolidin-1-yl)benzamide

https://huagongshe.com/reaction/1612501

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Hydroxy-5-(2-oxopyrrolidin-1-yl)benzoic acidHCID 22253027—
ReactantN-[(1S,2S,4R)-1-Benzyl-4-(cyclohex-1-enylethylcarbamoyl)-2-hydroxypentyl]-3-isopropoxy-5-(2-oxopyrrolidin-1-yl)benzamideHCID 69589915—
ProductN-[(1S,2S,4R)-1-Benzyl-4-(2-cyclohexylethylcarbamoyl)-2-hydroxypentyl]-3-isopropoxy-5-(2-oxopyrrolidin-1-yl)benzamideHCID 58583639—

Reaction Steps

Prepared in an analogous manner to D6 (hydrogenation stage) from N-[(1S,2S,4R)-1-benzyl-4-(cyclohex-1-enylethylcarbamoyl)-2-hydroxypentyl]-3-isopropoxy-5-(2-oxopyrrolidin-1-yl)benzamide (D51).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06992103B2
Source datasetuspto-grants-2006_01
ORD IDord-ffc58ff06a5049ae91fcf7ad3d432f5a
Source noteuspto-grants-2006_01