HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylamine → N-[(1S,2S,4R)-1-Benzyl-4-(cyclobutylcarbamoyl)-2-hydroxypentyl]-2-fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | [(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-carbamic acid t-butyl ester | HCID 69507916 | — |
| Reactant | 2-Fluoro-N-[(S)-1-((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)-2-phenylethyl]-3,5-bis-(2-oxopyrrolidin-1-yl)benzamide | HCID 69589694 | — |
| Product | N-[(1S,2S,4R)-1-Benzyl-4-(cyclobutylcarbamoyl)-2-hydroxypentyl]-2-fluoro-3,5-bis-(2-oxopyrrolidin-1-yl)benzamide | HCID 10218586 | — |
Reaction Steps
Prepared in an analogous manner to D1 from cyclobutylamine and 2-fluoro-N-[(S)-1-((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)-2-phenylethyl]-3,5-bis-(2-oxopyrrolidin-1-yl)benzamide (D50).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992103B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-0280fb60fb364e4682a3fb0c9e58ce09 |
| Source note | uspto-grants-2006_01 |